The Chief Rabbi appeared to be caught off guard on live BBC radio suggesting that the conflict in Gaza was fuelled by tensions in the region over Iran.
Lord Sacks had just completed one of his regular Thought for the Day broadcasts on BBC Radio 4 when he was asked by the Today programme presenter, Evan Davis, if he had any thoughts on the clashes in the Middle East.
The Orthodox Jewish leader paused and sighed audibly, before suggesting that Iran was the real issue behind the crisis.
Mr Daviss informal style has won plaudits for BBC radios flagship news programme since he joined the presenting team.
He frequently makes unscripted interjections usually after another presenter has finished interviewing a guest - and asks the interviewee for a view on an unexpected subject, before moving to the next item.
However this approach appeared momentarily to confuse the Chief Rabbi today.
Mr Davis said: Jonathan, before you go, you know, any thoughts on whats going on over in Israel and Gaza at the moment?
Lord Sacks sighed, before replying: I think it has got to do with Iran, actually.
Mr Daviss co-presenter, Sarah Montague, was clearly concerned that Lord Sacks did not seem to know his remarks were still being broadcast and could be heard to whisper: We, were live.
Lord Sacks then swiftly adopted a more formal broadcasting manner and suggested the crisis demanded a continued prayer for peace, not only in Gaza but for the whole region.
No-one gains from violence. Not the Palestinians, not the Israelis. This is an issue here where we must all pray for peace and work for it, he said.
Mr Davis thanked his guest and announced that the programme would move on to the next item.
As the most prominent Orthodox Jew in Britain, Lord Sackss remarks on tensions in the Middle East are always closely scrutinised.
In an official statement on the escalating crisis between Gaza and Israel yesterday, he offered support for the Israelis right to defend themselves.
In the past week alone over 275 rockets have been fired into southern Israel from Gaza, he said. No nation on earth can be expected to live under this constant threat to innocent life.
The people of Israel are entitled, as is any other nation, to live in peace and safety. We mourn with all the bereaved families, and pray for an end to the hostilities from which both sides suffer.
Last night, David Cameron spoke by telephone to the Israeli Prime Minister, Benjamin Netanyahu, to discuss the situation following Israel's assassination of Ahmed Jabari, the Hamas military chief, in a drone strike on his car on Wednesday.
In a statement after the talks, Downing Street said the government believed Hamas bears principal responsibility for the escalating crisis.
A spokesman added: The Prime Minister said that the priority must be to de-escalate the crisis.
He called on Mr Netanyahu to do all he could to avoid civilian casualties and emphasised that both sides needed to avoid a spiral of violence that would be in no-one's interest, particularly at a time of instability in the region.
Iran has condemned Israels attacks on Gaza as terrorism.
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